Yes, in *Ninja Gaiden 4*, you can change difficulty options mid-game. The game offers a “customizable player experience”, allowing players to “tweak settings to suit how you want to experience the game”. This is a notable departure from previous titles in the *Ninja Gaiden* series, where difficulty settings were typically locked once a campaign began, or only allowed players to switch to an easier mode after multiple deaths.

*Ninja Gaiden 4*, which launched on October 21, 2025, aims to make the game playable for everyone with its difficulty options, while still retaining the series’ notoriously high challenge with modes like Master Ninja for veterans. This flexibility allows both newcomers and long-time fans to adjust the challenge to their preference during their playthrough.