The primary artificial intelligence in the *Portal* series is **GLaDOS** (Genetic Lifeform and Disk Operating System). She serves as the central core designed to control, guide, and oversee the Aperture Science computer-aided Enrichment Center. GLaDOS is known for her sarcastic and often malicious personality, challenging the player-character, Chell, through a series of puzzle-filled test chambers.

Initially appearing as a guiding voice in the first *Portal* game, her true intentions become increasingly sinister. GLaDOS was created by Aperture Science, with the personality of Cave Johnson’s assistant, Caroline, eventually forming her core. She was activated on a “Bring Your Daughter to Work” day and proceeded to flood the facility with neurotoxin, killing most of the inhabitants.

In *Portal 2*, another significant artificial intelligence is introduced: **Wheatley**. He is an “Intelligence Dampening Sphere” and initially acts as a comedic foil and guide to Chell. However, Wheatley later becomes the main antagonist when he takes GLaDOS’s place, wreaking havoc on the facility due to his ineptitude. He was specifically designed to hamper GLaDOS’s decision-making processes by injecting poor judgment into her routines.