In the Dragon Quest 3 HD-2D Remake, players can acquire the Poison Needle through various means. One of the simplest ways is to purchase it for just 10 gold pieces from shops like Khoryv. Additionally, players can find this item in treasure chests located on the Ghost Ship and in Khoryv itself, offering more opportunities to obtain it without spending gold.

Moreover, the Poison Needle can be acquired through combat as certain monsters, including Betterflies and Hoodies, have a chance to drop it when defeated. For those looking for a stealthy approach, it can also be stolen from the shopkeeper in Corov village during nighttime, providing another unique method of acquisition. Overall, players have multiple avenues to obtain this item, catering to different playstyles and strategies within the game.